Acute toxicity, hepato-curative activity of extracts of a combination of plants on CCL4-induced hepatotoxicity in rats and antiradical activity

Traditional healers combine four medicinal plants (Cochlospermum tinctorium, Terminalia macroptera, Leptadenia hastata and Commiphora Africana to treat hepatitis in Burkina Faso. The aimed was evaluate the hepato-curative activity of lyophilized aqueous decoction (LAD) hydroethanolic macerate (LHM) plant extracts on CCl4-induced rats. We assessed acute toxicity scavenging 2, 2-Diphenyl-1-picrylhydrazyl (DPPH). Hepato-curative study included nine groups with five rats each. used as followed: group 1 neutral controls, 2 negative other were experimental groups. Rats 2-9 received a single dose (1 mL/kg) CCl4 intraperitoneal injection induce hepatitis. fed orally for seven consecutive days sylimarin 3, LAD LHM respectively 4-6 7-9 by 400, 200 100 mg/kg/day. This revealed had LD50> 2000 mg/kg both showed radical-scavenging properties IC50= 5.95 8.66 µg/mL respectively. All regardless treatment significantly reduced plasma transaminases level compared controls. at alkaline phosphatase gamma-glutamyl transferase. Histologically, treated normal almost liver dose-dependent manner Conclusion: decreased enzyme allowed dose-Dependent damage recovery after